Background: Diabetes Mellitus is the most common endocrinologic disease in human and retinopathy is one of the most common complications. Etiology of this complication is yet unknown but one of the factors that can be effective on its production or progression is serum lipid. We aim to study the relationship between different degrees of diabetic retinopathy and serum lipids levels. Methods: An observational cross-sectional study designed to study over 37 patients with diabetes mellitus type one and 157 patients with diabetes mellitus type two. Former was selected as sensus and latter was selected randomly from diabetic patients attending the diabetes clinic in Yazd during 2002. Inclusion criteria were duration of diabetes at least seven years from diagnosis. Statistical analysis performed by SPSS package edition 11 and wit statistical tests as Chi square, Fisher Exact and ANOVA.Results: Among 194 cases, 74 cases were males and 120 females. 90 cases (46.4%) have normal total serum cholesterol and 104 (53.6%) hypercholestrolemia. In case of triglyceride 94 cases (48.4%) have normal serum triglyceride and 100 (51.6%) hypertriglyceridemia. Distribution of different degrees of diabetic retinopathy was statistically significant due to cholesterol and triglycerides (P-Value<0.05). In different groups of sex, diabetic retinopathy was more prevalent if there was hypertriglyceridemia or hypercholesterolemia. This was correct about different groups of age and type of diabetes. This means that in different groups of age and type of diabetes, diabetic retinopathy was more prevalent if there was hypertriglyceridemia or hypercholesterolemia.Conclusion: Prevalence of diabetic retinopathy is higher in cases with hypertriglyceridemia or hypercholesterolemia than cases with normal serum triglyceride or cholesterole.

Introduction: Psoriasis is a common chronic inflammatory skin disease. Cardiovascular diseases have been reported with greater frequency in patients with Psoriais. This may result from hyperlipidemia which seen in these patients. The aim of this study was to further study profiles of serum lipids and to determine, if any, correlation between severity of disease and extent of hyperlipidemia in these patients. Material and Methods: Subjects consisted of 52 patients with Psoriasis and 50 matched (sex and age) healthy persons as a control group. Blood samples were obtained following 14 hour fasting status and serum levels of triglyceride, cholesterol, HDL, LDL, VLDL were determined using standard laboratory methods.Results: Our findings showed that levels of TG, cholesterol, LDL and VLDL were significantly higher in psoriatic patients when compared with control ones (p< 0.001), but HDL level was similar between two groups. Also, any relationship was not found between lipids levels and severity of disease.Conclusion: Our findings further confirm lipid abnormalities in Psoriatic patients. This may enhance risk of cardiovascular diseases in these patients. Thus, we recommend all patients with Psoriasis, regardless of disease severity, should be checked for serum lipids profiles.

Objective: Diabetes is the most common metabolic disease. One of the most common problems in diabetic patients is atherosclerotic cardiovascular disease which induced by hyperlipidemia. Also there has been currently great interest in the potential contribution of oxidative stress in development of diabetes complications. The present study was performed to associate between lipid oxidizability and serum lipid levels in diabetic patients.Materials and Methods: In this study, 55 diabetic patients in Yazd Diabetes Research Center were chosen. Lipid oxidizability, HbA1c and serum lipid levels were analyzed in patients. Lipids were measured by enzymatic method. HbA1c was estimated by the ion exchange chromatography. The lipid oxidation procedure was performed by addition of CuCl2. The kinetics of conjugated dienes formation was monitored by spectrophotometer and parameters such as ODmax, Lag Time, Vmax and Tmax were analyzed.Result: In present study, there was no association between lipid oxidizability and serum lipids levels. Also there was no association between lipid oxidizability parameters and HbA1c.Conclusion: This study showed that high levels of blood lipids such as cholesterol and triglyceride do not have any effect on maximal amount of lipids peroxide products accumulation and maximal rate of oxidation during the lipid oxidation course.

Objective: Metabolic disturbances such as obesity, diabetes mellitus, and dyslipidemias are among the most important medical problems. Dysipidemias are among the most important causes of atherosclerosis and coronary heart disease (CHD). Exercise has protective effects against coronary arterial disease. Incidence of hyperlipidemia is high in Iran. This study was performed to delineate the level of physical activity and its influence on serum lipids. Materials and Methods: An epidemiological cross-sectional study was carried out on about 11000 persons selected randomly in Tehran urban district 13 with a minimum age of 20 years and over. We measured fasting blood sugar, 2 hours after 75 grams oral glucose, triglyceride, total cholesterol, LDL cholesterol, HDL cholesterol, alkaline phosphatase and TSH. Degree of physical activity was registered according to the lipid research clinics classification and anthropometrical data were exactly delineated. Social status, family history and smoking were also delineated. Our patients were divided into two groups: those having normal lipid profile and dyslipidemics. The latter group was further divided into two subgroups: primary (without any risk factor for dyslipidemia) and secondary (having one or more risk factors such DM...). Results: In our study the total prevalence of dyslipidemias was 68.5%. According to the degree of physical activity all participants were divided into three groups: Low (62.8%), moderate (13%) and high physical activity (24.2%). Prevalence of dyslipidemia was 69.4%, 68.5%, and 65.5% respectively. Conclusion: The Tehran of population suffers from dyslipidemia. Low physical activity is one of the known causes of dyslipidemia and in our study this relation was delineated but also low physical activity found to be popular.    

Introduction: Hyperlipidemia is one of the main known risk factors for coronary artery disease. Regarding the undesirable consequences of hyperlipidemia and its long-term treatment, it is important to use drugs with lesser complications during the long period of treatment.Materials and Methods: This study was a double-blind randomized clinical trail that carried out on 65 patients with hyperlipidemia. Patients were divided into two groups. Case groups took dill pearl, and control group took placebo pearl for one month. Serum lipids of both groups were measured before and one month after interference. Data was analysed with t-test and p<0.05 was considered significant.Results: In this study , differences between mean level of cholesterol, triglyseride, HDL and LDL in case group before and after interference were statistically significant (P<0/05) but in control group only difference between HDL before and after interference was significant .Conclusion: Regarding the result of the study dill pearl can be a useful drug for treatment of hyperlipidemia.

Objectives: The aim of this project was to evaluate the intensity of anxiety and its relation with hypertension, the level of serum lipids, and symptoms of cardiovascular diseases. Method: 606 males and females between the ages of 35-65 residing in Tehran were selected by random-cluster sampling and participated as the subjects of this descriptive-cross sectional study. The subjects blood pressure, serum lipids (via enzymatic methods), and symptoms of cardiovascular diseases were evaluated by physicians. The intensity of their anxiety was determined by Zigmond and Snaith questionnaires. Data were analyzed by t-test, analysis of variance, and c2. Findings: The intensity of anxiety was observed significantly more in women than men. There was a significant correlation between the intensity of anxiety with systolic and diastolic hypertension and low levels of HDL Cholesterol. However, there was not a significant correlation between the intensity of anxiety with total Cholesterol, LDL Cholesterol, and triglycerides. Neither was there a significant correlation between the intensity of anxiety with chest pain, palpitation, and myocardial failure. Results: Presence of anxiety is related to some risk factors for cardiovascular diseases.

BACKGROUND: Psoriasis is a common chronic and recurrent inflammatory skin disorder characterized by hyperproliferation of keratinocytes and infiltration of T cells, monocytes/macrophages and neutrophils into dermal and epidermal layers of the skin. The prevalence of cardiovascular disorders in these patients is remarkably higher compared to normal individuals, which seems to be associated with the hyperlipidemia. This study was designed and conducted to investigate the serum lipid profile in psoriatic patients and its association with the severity of disease.MATHERIALS AND METHODS: This case-control study was performed on 50 plaque-type psoriasis patients and 50 healthy individuals as control, matched for age and sex. Blood samples were collected after 14 h fasting. Serum triglyceride, cholesterol and lipoproteins were assayed using the standard kit (made by Pars Azmon Co. Iran).RESULTS: Certain parameters, including serum triglyceride, cholesterol, low density lipoprotein (LDL), and very low density lipoprotein (VLDL), were significantly higher in the case group compared to the controls (P < 0.001), while high density lipoprotein (HDL) was significantly lower in the former (P < 0.001). In addition, there was a significant relationship between severity of psoriasis and serum lipid profile.CONCLUSION: The results have revealed the higher plasma level of lipids in psoriatic patients. This may elevate the risk of atherosclerosis, particularly cardiovascular disorders. Therefore, from the epidemiological point of view, screening psoriatic patients, particularly those with severe psoriasis, is recommended.

BACKGROUND AND OBJECTIVE: Raloxifen is used widely to prevent menopause complications.Hyperlipidemia is a risk factor for coronary heart disease in menopausal women. There are controversies about raloxifen effects on serum lipids, so this study was done to determine the effects of raloxifen (ralofen) on serum lipids of the menopausal women.METHODS: This before - after interventional study was done on 50 menopausal women that returned to menopausal clinic of Yahyanejad hospital in Babol in 2008. Inclusion criteria were 45-60 years old and past of one year of last menstural period. Exclusion criteria were history of cancer, abnormal uterus bleeding, clotting dysfunction, use of androgen, corticosteroid and estrogen, renal failure, chronic and acute disease of liver, history of deep vein thrombosis and cardiovascular disease. Patient received ralofen (product by Aboryhan company) 60 mg/day for three months. Serum lipid level measured in three times include: before treatment, one month and three month later.FINDINGS: The mean age (±SD) of the patients was 53.2±3.7 and the median time of last menstural period was 6 years. The mean level of serum triglyceride (mg/dl) of menopausal women was significant (p=0.012) before treatment (159.6±36.1 mg/dl), one month after treatment (162.9±34.8 mg/dl) and three month after treatment (170.8±41.7 mg/dl). So the mean level of serum cholesterol (mg/dl) of menopausal women was significant (p=0.000) before treatment (193.6±22.2 mg/dl), one month after treatment (198.6±24.9 mg/dl) and three month after treatment (202.1±26.7 mg/dl).The mean level of serum LDL (mg/dl) of menopausal women was not significant (p=0.152) before treatment (114.6±28.3 mg/dl), one month after treatment (118.8±29.6 mg/dl) and three month after treatment (113.9±26.7 mg/dl). So the mean level of serum HDL (mg/dl) of menopausal women was not significant before treatment (47.8±9.3 mg/dl), one month after treatment (46.7±8.5 mg/dl) and three months after treatment (48.2±5.8 mg/dl).CONCLUSION: This study showed that ralofen had no significant effects on serum lipids levels and triglyceride and cholesterol increased were in normal and borderline limits that don't have clinical importance.